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    Disciplines / Research questions

    农业科学

    20 个研究主题 · 53 个问题

    布鲁氏菌的持续性感染2 个问题

    1. Intracellular Brucella persisters: mechanisms of formation, physiological state, niche determinants, clinical relevance, and therapeutic targeting

    2. Functional significance and developmental origin of splenic CD11c⁺CD205⁺ arginase-1⁺ lipid-rich reservoir cells sustaining chronic Brucella infection

    果实着色的成因2 个问题

    1. Identifying the HY5-independent UV-B pathway that up-regulates anthocyanin repressor VcMYBC2 in mature highbush blueberry fruit

    2. Temperature sensing and the causal role of DNA demethylation in 16°C-dependent anthocyanin accumulation in peach flesh

    果树童期2 个问题

    1. Direct functional roles of the apple FLOWERING LOCUS C homologs MdFLC1 and MdFLC3 in juvenility and MdFT regulation, and whether they can serve as markers of juvenile-period length

    2. Mechanism and applicability limits of Apple latent spherical virus-mediated early flowering in apple: why AtFT expression combined with MdTFL1-1 silencing succeeds where endogenous MdFT1/MdFT2 fail

    花卉器官瓣化及变型的原因4 个问题

    1. Molecular cause of whorl-3-specific AGAMOUS-like (LelAG1) down-regulation and its causal role in graded stamen petaloidy of the double-flowered lily 'Elodie'

    2. Mechanistic basis of androecial petaloidy in Canna indica: divergent fates of petaloid staminodes and the fertile stamen despite co-expressed B- and C-class floral identity genes

    3. Genetic and regulatory basis of sepal petaloidy and B-class-dependent C-domain boundary maintenance in Aquilegia (Ranunculaceae)

    4. Functional validation of the candidate regulatory network for stamen petaloidy in Lagerstroemia speciosa

    黄土高原生态环境退化过程及其修复机理3 个问题

    1. Recovery, precipitation-zone mechanisms, and management thresholds for deep soil water depletion after revegetation on the Loess Plateau

    2. Permanence, recovery, and process attribution of afforestation-induced deep soil moisture decline on China's Loess Plateau

    3. Causal role and mechanisms of glomalin-related soil protein in soil aggregation and nutrient recovery during natural revegetation on the Loess Plateau

    林木基因型与环境1 个问题

    1. Range-wide drought-resilience clines and the mechanistic basis of post-drought growth recovery in white spruce (Picea glauca)

    林木生物质超微结构的分子解译2 个问题

    1. The molecular structure of cellulose microfibrils in spruce wood: chain number, packing, and twist

    2. Physical driving forces of the carbohydrate-aromatic interface in lignocellulosic cell walls: conformation-selective lignin-xylan association, crowding-enforced binding at cellulose-xylan junctions, and hydration of the molecularly mixed aromatic phase

    木材形成的遗传调控4 个问题

    1. Causally validating the coordinated photosynthesis–wood formation regulatory network in Populus tomentosa: noncoding causal variants, in-planta mechanisms, multi-omic completeness, and adaptive shaping

    2. Functional validation of the eQTL-predicted regulatory network of wood formation in Salix suchowensis: master regulators, a putative WUS/CLV-like cambium module, and joint phytohormone coordination

    3. Experimental validation of the divergent conifer wood-formation program: polysaccharide O-acetylation and secondary-cell-wall transcriptional regulation

    4. Mechanistic basis of ethylene action in Populus wood formation: lateral ACC distribution and the in-vivo functions of EIN3D and ERF transcription-factor hubs

    牛奶中乳脂肪和乳蛋白的合成机制2 个问题

    1. Mechanisms of diet-induced milk fat depression: mammary sensing of trans-10 biohydrogenation fatty acids and the ruminal trans-11 to trans-10 shift

    2. From transcript network to mechanism: validating protein-level function, PPARG–PPARGC1A–INSIG1–SREBF causality, ABCG2 cargo, and flux-level control of bovine milk fat synthesis across the lactation cycle

    农业机械耕作部件仿生降阻2 个问题

    1. Physical validation, robustness, and systematic optimization of mole-cricket claw-toe bionic subsoiling shovels for red soil

    2. Parameterizing and grounding the bionic nonsmooth drag-reduction design model for subsoiling: the recovery acceleration a, the fluctuation correction index k, and the bulge height-spacing-speed relation

    人类疾病的动物模型2 个问题

    1. Quantifying the limits of compendium-based mouse-to-human transcriptomic translation: scaling with training data, failure domains such as cancer, and validation against discordant human references

    2. Predictive validity of animal models of type 2 diabetes for human antidiabetic-drug efficacy

    森林生态系统的多样性与病虫害消长的关系3 个问题

    1. Conditions and mechanisms of tree-diversity effects on insect herbivory in forests: the open agenda of associational-resistance research

    2. Causality, mechanisms, and transferability of tree-diversity regulation of nonnative forest pest invasion (concurrent facilitation and dilution)

    3. When tree diversity protects and when it exposes: the sign and context dependence of associational effects on forest pest and pathogen damage

    水产品质量标准的科学基础2 个问题

    1. Probabilistic quantification of the conservatism in point-estimate dietary exposure assessments used to set Maximum Residue Limits for veterinary drugs

    2. Validated chemical acceptance criteria on washed mince for tracing raw-material freshness of tropical surimi

    水的聚集态及功能性质4 个问题

    1. Energetic and kinetic characterization of hydrogen-bond coordination defects in ab initio liquid water

    2. Robustness, cross-term corrections, and causal thermodynamic significance of the ring-topological origin of the split first peak in liquid water's structure factor

    3. Cavitation of Water in Hydrophobic Graphene Slit Pores Narrower than 6.5 Å and the Fine Structure of the Confinement Free Energy near 14 Å

    4. A theoretical model linking solute-induced hydrogen-bond rearrangement in water to the solvatochromic solvent features of aqueous solutions

    土壤微生物多样性3 个问题

    1. Causal directionality and independent validation of the global soil carbon–microbial biomass–diversity coupling

    2. Mechanism and generality of microbial diversity control over soil heterotrophic respiration and its response to moisture increase (open question from Zhang & Zhang 2016)

    3. Multi-factor global change effects on soil microbial diversity: long-term interactive responses, precipitation double-asymmetry, elevated-CO2 mechanisms, wetting-drying-adapted taxa, and mitigation of nitrogen-driven loss

    养殖鱼类早期发育阶段为什么死亡率高4 个问题

    1. Causal attribution of hatchery-phase mortality in farmed lumpfish (Cyclopterus lumpus): the fin-lesion/infection direction, tank-level risk factors, and the standardized monitoring needed to resolve them

    2. Generalizing the validated twelve-factor pikeperch (Sander lucioperca) larviculture protocol: robustness across rearing contexts and broodstock, ontogeny-matched dynamic regimes, and farm-level transfer

    3. First-feeding survival and the mechanisms of delayed-feeding mortality in silver therapon (Leiopotherapon plumbeus) larvae after yolk resorption

    4. Unresolved cores of the early mortality of cultured larvae of the Asian catfish Pangasianodon hypophthalmus: oral-spine histology, wound-to-infection causality, and wild-larval relevance

    营养与动物健康4 个问题

    1. Causal direction of prepartal hepatic transcriptomic and metabolic remodeling in the development of clinical ketosis in dairy cows

    2. Mechanistic links between prepartum energy overfeeding, periparturient inflammation, and hepatic lipid accumulation in transition dairy cows

    3. Durability, reversibility, and mechanisms of early weaning-diet metabolic and immune imprinting in the pig, and the causal role of gut microbiota

    4. Mechanistic basis and energy-versus-protein attribution of the growth–immunity trade-off under chronic dietary energy restriction in growing ruminants

    鱼类为什么不能很好地利用糖类物质？2 个问题

    1. Dietary carbohydrate utilization in juvenile common snook (Centropomus undecimalis) and yellowtail snapper (Ocyurus chrysurus): the mechanistic basis of species-differentiated postprandial hyperglycemia, optimal inclusion levels and sources, and long-term metabolic consequences

    2. Mechanism and quantitative prediction of non-starch polysaccharide digestion in Nile tilapia (Oreochromis niloticus)

    杂种优势的遗传基础3 个问题

    1. The molecular identity and mechanistic basis of the dosage-sensitive component of heterosis

    2. Resolving the locus-level non-additive architecture of rice heterosis: distinguishing true overdominance from pseudo-overdominance and making non-additive effects predictive

    3. Genetic decomposition of grain-yield heterosis in bread wheat: separating genuine epistasis from linkage artifacts and quantifying the unassessed components

    针刺效应的生物学机制2 个问题

    1. Generalization and mechanistic dissection of the fibroblast–SCF/IL-33–mast cell–neuron signaling axis initiated by manual acupuncture

    2. The acupoint-to-brain signaling mechanism behind mTOR-independent autophagic clearance of α\alpha-synuclein after acupuncture at GB34

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