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    Disciplines / Research questions

    Agriculture

    20 research topics · 53 questions

    Persistent Infection of Brucella2 questions

    1. Intracellular Brucella persisters: mechanisms of formation, physiological state, niche determinants, clinical relevance, and therapeutic targeting

    2. Functional significance and developmental origin of splenic CD11c⁺CD205⁺ arginase-1⁺ lipid-rich reservoir cells sustaining chronic Brucella infection

    Causes of Fruit Coloring2 questions

    1. Identifying the HY5-independent UV-B pathway that up-regulates anthocyanin repressor VcMYBC2 in mature highbush blueberry fruit

    2. Temperature sensing and the causal role of DNA demethylation in 16°C-dependent anthocyanin accumulation in peach flesh

    Juvenile Period in Fruit Trees2 questions

    1. Direct functional roles of the apple FLOWERING LOCUS C homologs MdFLC1 and MdFLC3 in juvenility and MdFT regulation, and whether they can serve as markers of juvenile-period length

    2. Mechanism and applicability limits of Apple latent spherical virus-mediated early flowering in apple: why AtFT expression combined with MdTFL1-1 silencing succeeds where endogenous MdFT1/MdFT2 fail

    Causes of Floral Organ Petalization and Transformation4 questions

    1. Molecular cause of whorl-3-specific AGAMOUS-like (LelAG1) down-regulation and its causal role in graded stamen petaloidy of the double-flowered lily 'Elodie'

    2. Mechanistic basis of androecial petaloidy in Canna indica: divergent fates of petaloid staminodes and the fertile stamen despite co-expressed B- and C-class floral identity genes

    3. Genetic and regulatory basis of sepal petaloidy and B-class-dependent C-domain boundary maintenance in Aquilegia (Ranunculaceae)

    4. Functional validation of the candidate regulatory network for stamen petaloidy in Lagerstroemia speciosa

    The Degradation Process of the Loess Plateau Ecological Environment and Its Restoration Mechanism3 questions

    1. Recovery, precipitation-zone mechanisms, and management thresholds for deep soil water depletion after revegetation on the Loess Plateau

    2. Permanence, recovery, and process attribution of afforestation-induced deep soil moisture decline on China's Loess Plateau

    3. Causal role and mechanisms of glomalin-related soil protein in soil aggregation and nutrient recovery during natural revegetation on the Loess Plateau

    Genotype and Environment of Forest Trees1 questions

    1. Range-wide drought-resilience clines and the mechanistic basis of post-drought growth recovery in white spruce (Picea glauca)

    Molecular Interpretation of Forest Tree Biomass Ultra-Structure2 questions

    1. The molecular structure of cellulose microfibrils in spruce wood: chain number, packing, and twist

    2. Physical driving forces of the carbohydrate-aromatic interface in lignocellulosic cell walls: conformation-selective lignin-xylan association, crowding-enforced binding at cellulose-xylan junctions, and hydration of the molecularly mixed aromatic phase

    Genetic Regulation of Wood Formation4 questions

    1. Causally validating the coordinated photosynthesis–wood formation regulatory network in Populus tomentosa: noncoding causal variants, in-planta mechanisms, multi-omic completeness, and adaptive shaping

    2. Functional validation of the eQTL-predicted regulatory network of wood formation in Salix suchowensis: master regulators, a putative WUS/CLV-like cambium module, and joint phytohormone coordination

    3. Experimental validation of the divergent conifer wood-formation program: polysaccharide O-acetylation and secondary-cell-wall transcriptional regulation

    4. Mechanistic basis of ethylene action in Populus wood formation: lateral ACC distribution and the in-vivo functions of EIN3D and ERF transcription-factor hubs

    Mechanisms of Milk Fat and Milk Protein Synthesis in Milk2 questions

    1. Mechanisms of diet-induced milk fat depression: mammary sensing of trans-10 biohydrogenation fatty acids and the ruminal trans-11 to trans-10 shift

    2. From transcript network to mechanism: validating protein-level function, PPARG–PPARGC1A–INSIG1–SREBF causality, ABCG2 cargo, and flux-level control of bovine milk fat synthesis across the lactation cycle

    Bionic Resistance Reduction in Agricultural Machinery Tillage Components2 questions

    1. Physical validation, robustness, and systematic optimization of mole-cricket claw-toe bionic subsoiling shovels for red soil

    2. Parameterizing and grounding the bionic nonsmooth drag-reduction design model for subsoiling: the recovery acceleration a, the fluctuation correction index k, and the bulge height-spacing-speed relation

    Animal Models of Human Diseases2 questions

    1. Quantifying the limits of compendium-based mouse-to-human transcriptomic translation: scaling with training data, failure domains such as cancer, and validation against discordant human references

    2. Predictive validity of animal models of type 2 diabetes for human antidiabetic-drug efficacy

    Diversity of Forest Ecosystems and Its Relationship with Pest and Disease Dynamics3 questions

    1. Conditions and mechanisms of tree-diversity effects on insect herbivory in forests: the open agenda of associational-resistance research

    2. Causality, mechanisms, and transferability of tree-diversity regulation of nonnative forest pest invasion (concurrent facilitation and dilution)

    3. When tree diversity protects and when it exposes: the sign and context dependence of associational effects on forest pest and pathogen damage

    Scientific Basis of Aquatic Product Quality Standards2 questions

    1. Probabilistic quantification of the conservatism in point-estimate dietary exposure assessments used to set Maximum Residue Limits for veterinary drugs

    2. Validated chemical acceptance criteria on washed mince for tracing raw-material freshness of tropical surimi

    Aggregated States and Functional Properties of Water4 questions

    1. Energetic and kinetic characterization of hydrogen-bond coordination defects in ab initio liquid water

    2. Robustness, cross-term corrections, and causal thermodynamic significance of the ring-topological origin of the split first peak in liquid water's structure factor

    3. Cavitation of Water in Hydrophobic Graphene Slit Pores Narrower than 6.5 Å and the Fine Structure of the Confinement Free Energy near 14 Å

    4. A theoretical model linking solute-induced hydrogen-bond rearrangement in water to the solvatochromic solvent features of aqueous solutions

    Soil Microbial Diversity3 questions

    1. Causal directionality and independent validation of the global soil carbon–microbial biomass–diversity coupling

    2. Mechanism and generality of microbial diversity control over soil heterotrophic respiration and its response to moisture increase (open question from Zhang & Zhang 2016)

    3. Multi-factor global change effects on soil microbial diversity: long-term interactive responses, precipitation double-asymmetry, elevated-CO2 mechanisms, wetting-drying-adapted taxa, and mitigation of nitrogen-driven loss

    Why Mortality Is High in Early Development Stages of Farmed Fish4 questions

    1. Causal attribution of hatchery-phase mortality in farmed lumpfish (Cyclopterus lumpus): the fin-lesion/infection direction, tank-level risk factors, and the standardized monitoring needed to resolve them

    2. Generalizing the validated twelve-factor pikeperch (Sander lucioperca) larviculture protocol: robustness across rearing contexts and broodstock, ontogeny-matched dynamic regimes, and farm-level transfer

    3. First-feeding survival and the mechanisms of delayed-feeding mortality in silver therapon (Leiopotherapon plumbeus) larvae after yolk resorption

    4. Unresolved cores of the early mortality of cultured larvae of the Asian catfish Pangasianodon hypophthalmus: oral-spine histology, wound-to-infection causality, and wild-larval relevance

    Nutrition and Animal Health4 questions

    1. Causal direction of prepartal hepatic transcriptomic and metabolic remodeling in the development of clinical ketosis in dairy cows

    2. Mechanistic links between prepartum energy overfeeding, periparturient inflammation, and hepatic lipid accumulation in transition dairy cows

    3. Durability, reversibility, and mechanisms of early weaning-diet metabolic and immune imprinting in the pig, and the causal role of gut microbiota

    4. Mechanistic basis and energy-versus-protein attribution of the growth–immunity trade-off under chronic dietary energy restriction in growing ruminants

    Why Fish Cannot Efficiently Utilize Carbohydrates2 questions

    1. Dietary carbohydrate utilization in juvenile common snook (Centropomus undecimalis) and yellowtail snapper (Ocyurus chrysurus): the mechanistic basis of species-differentiated postprandial hyperglycemia, optimal inclusion levels and sources, and long-term metabolic consequences

    2. Mechanism and quantitative prediction of non-starch polysaccharide digestion in Nile tilapia (Oreochromis niloticus)

    Genetic Basis of Heterosis3 questions

    1. The molecular identity and mechanistic basis of the dosage-sensitive component of heterosis

    2. Resolving the locus-level non-additive architecture of rice heterosis: distinguishing true overdominance from pseudo-overdominance and making non-additive effects predictive

    3. Genetic decomposition of grain-yield heterosis in bread wheat: separating genuine epistasis from linkage artifacts and quantifying the unassessed components

    Biological Mechanism of Acupuncture Effects2 questions

    1. Generalization and mechanistic dissection of the fibroblast–SCF/IL-33–mast cell–neuron signaling axis initiated by manual acupuncture

    2. The acupoint-to-brain signaling mechanism behind mTOR-independent autophagic clearance of α\alpha-synuclein after acupuncture at GB34

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