Scientists / Open questions

Leon N. Cooper

Superconductivity; neuroscience

1972 Nobel Prize in Physics

39 questions

Convergence, decision-boundary structure, and biophysical implementation of Restricted Coulomb Energy prototype learning
Extensions of outlier-robust time-of-flight estimation beyond the narrow-band Gaussian regime: multi-sidelobe and non-Gaussian analytic models, robustness to training-deployment mismatch, and phase-shift bank design
Molecular substrate and developmental gating of experience-dependent synaptic modification in visual cortex: open questions in the Cooper–Imbert (1981) agenda
Autonomous and principled selection of fixation regions for Bayesian integrate-and-shift (BIAS) object-category learning
Identification of the exotic negative ions in superfluid helium-4 and experimental test of the fission of the electron wave function
Molecular implementation and quantitative parameters of homosynaptic (BCM) synaptic plasticity in neocortex
Microscopic stochastic foundation of the AMPAR-phosphorylation switch for bidirectional synaptic plasticity: chemical-master-equation formulation, CaMKII-autophosphorylation multistability, the BCM correspondence, and experimental tests
Open problems left by the Cooper–Liberman–Oja (1979) threshold-passive-modification theory of neuron specificity in visual cortex: the labile/non-labile synapse substrate and the uncompleted population-level mathematics of acquisition, loss, and recovery
Exposure-regimen dependence and mammalian translatability of the low-dose radiation threshold effect in Drosophila melanogaster
Coupled-boson mass generation in one-dimensional conductors: the unresolved questions of the 1978 Berkcan–Cooper variational program
Validating the irradiated-Drosophila gene-expression dosimeter panel: cross-species translation to humans, temporal window, and dependence on radiation energy and type
Experimental determination of the biophysical mechanisms and parameters underlying the inter-spike interaction of spike-timing-dependent plasticity in cortex
Semi-coherent echo processing with phase-shifted unmatched filters: the open signal-detection extension and generalization beyond the simulated narrowband setting
Proper completions of truncated many-body perturbation expansions: existence, uniqueness, construction, and EPV-free computation
Tying the BCM theory of visual cortical development to experiment: in-vivo sliding of the modification threshold, quantitative dependence of deprivation outcomes on residual activity statistics, spontaneous-activity boundary conditions, and single-cell versus network predictions

Back to open problems

Convergence, decision-boundary structure, and biophysical implementation of Restricted Coulomb Energy prototype learning

Extensions of outlier-robust time-of-flight estimation beyond the narrow-band Gaussian regime: multi-sidelobe and non-Gaussian analytic models, robustness to training-deployment mismatch, and phase-shift bank design

Molecular substrate and developmental gating of experience-dependent synaptic modification in visual cortex: open questions in the Cooper–Imbert (1981) agenda

Autonomous and principled selection of fixation regions for Bayesian integrate-and-shift (BIAS) object-category learning

Identification of the exotic negative ions in superfluid helium-4 and experimental test of the fission of the electron wave function

Molecular implementation and quantitative parameters of homosynaptic (BCM) synaptic plasticity in neocortex

Microscopic stochastic foundation of the AMPAR-phosphorylation switch for bidirectional synaptic plasticity: chemical-master-equation formulation, CaMKII-autophosphorylation multistability, the BCM correspondence, and experimental tests

Open problems left by the Cooper–Liberman–Oja (1979) threshold-passive-modification theory of neuron specificity in visual cortex: the labile/non-labile synapse substrate and the uncompleted population-level mathematics of acquisition, loss, and recovery

Exposure-regimen dependence and mammalian translatability of the low-dose radiation threshold effect in Drosophila melanogaster

Coupled-boson mass generation in one-dimensional conductors: the unresolved questions of the 1978 Berkcan–Cooper variational program

Validating the irradiated-Drosophila gene-expression dosimeter panel: cross-species translation to humans, temporal window, and dependence on radiation energy and type

Experimental determination of the biophysical mechanisms and parameters underlying the inter-spike interaction of spike-timing-dependent plasticity in cortex

Semi-coherent echo processing with phase-shifted unmatched filters: the open signal-detection extension and generalization beyond the simulated narrowband setting

Proper completions of truncated many-body perturbation expansions: existence, uniqueness, construction, and EPV-free computation

Tying the BCM theory of visual cortical development to experiment: in-vivo sliding of the modification threshold, quantitative dependence of deprivation outcomes on residual activity statistics, spontaneous-activity boundary conditions, and single-cell versus network predictions