Scientists / Open questions

利昂·库珀

Leon N. Cooper

超导理论、神经科学

1972 年诺贝尔物理学奖

39 个问题

Completing the Cooper–Van Vechten account of quantum measurement: thermodynamic irreversibility, basis selection, and reversible measurements within unitary quantum theory
Verification or refutation of the conscious-observer assumption in Cooper's no-collapse interpretation of quantum measurement
Robustness and calibration of CORaL's significant-set inference for ranked-list comparison: gene dependence, step-size selection, and operating regimes
Zero radius of convergence of the many-fermion linked-cluster expansion: extending Cooper's strongly coupled result to the full many-body problem and the fate of normal solutions at repulsive coupling
Completing and experimentally validating the unified calcium-based model of NMDA receptor-dependent bidirectional synaptic plasticity: metaplastic stabilization, non-NMDA calcium sources, and the predicted long-delay pre-post LTD window
Realistic stereo statistics and multi-component PCA in unsupervised models of ocular dominance and disparity tuning (questions left open by Shouval, Intrator, Law & Cooper, 1996)
Robustness and generality of orientation and ocular-dominance map formation in the BCM lateral-inhibition network trained on natural stereo images (Shouval–Intrator–Cooper, 1997)
Origin and experimental test of the lateral-connectivity scaffold for developing orientation preference maps in primary visual cortex
Multiple calcium entry pathways in the calcium-dependent plasticity model with calcium homeostasis: consequences for synaptic stability, input selectivity, and pathway dominance
Realistic-noise robustness, waveform generality, and SNR-estimate sensitivity of SNR-dependent unmatched-filter time-of-arrival estimation in high noise
Presynaptic release probability versus postsynaptic efficacy as the carrier of simple-cell receptive-field structure in visual cortex: an untested experimental discrimination and its consequences for spatiotemporal dynamics and coding under short-term synaptic depression
Completing the Bienenstock-Cooper-Munro theory of synaptic modification: first-principles form of the modification function, cortical circuitry, modulatory control, and general stability
Quantifying and causally testing deprived-eye lateral geniculate nucleus firing-rate correlations in monocular-inactivation ocular-dominance plasticity
Open problems in the non-equilibrium chemical master equation theory of phosphorylation–dephosphorylation cycles: energy cost of bistability, n-step generalization, cycle variants, transient dynamics, and flux-controlled plasticity
Establishing whether stochastic short-term synaptic and dendritic dynamics uniquely account for multi-spike synaptic plasticity in visual cortex and hippocampus
Open questions from Perrone and Cooper's Generalized Ensemble Method: finite-sample weight estimation, principled member selection, and ensemble saturation
Biophysical implementation of the BCM moving modification threshold and its functional dependence on postsynaptic activity
General analytical theory of the AOWA adaptive time-of-flight estimation scheme: multi-outlier-class extension, robustness to classifier mis-specification, and worst-case energy
Correlated-noise-induced long lifetimes of BCM synapses: robustness of the spectral mechanism beyond the linearized, uniform-correlation, thermodynamic-limit analysis, and its mapping to monocular-deprivation experiments
Quantitative validation of the calcium-dependent GluR1 phosphorylation model of bidirectional synaptic plasticity in intact dendritic spines
Regimes of validity and physiological grounding of the calcium-control-hypothesis (CaDP) framework of synaptic plasticity: parameters, rate-rule averaging, and the predicted pre-before-post LTD window
Open quantitative core of the Cooper–Stölan strongly coupled shell model: exact cycle-weight function f(α) with its analytic continuation f(−1), and the magnitude of the omitted non-BCS graphs
Breakdown of flux quantization by generalized pairing in superconducting cylinders: the Schwartz–Cooper intermediate-flux regime
Robustness of direction-selectivity formation in natural-scene environments to multi-delay architectures and cortical recurrence

返回开放问题

Completing the Cooper–Van Vechten account of quantum measurement: thermodynamic irreversibility, basis selection, and reversible measurements within unitary quantum theory

Verification or refutation of the conscious-observer assumption in Cooper's no-collapse interpretation of quantum measurement

Robustness and calibration of CORaL's significant-set inference for ranked-list comparison: gene dependence, step-size selection, and operating regimes

Zero radius of convergence of the many-fermion linked-cluster expansion: extending Cooper's strongly coupled result to the full many-body problem and the fate of normal solutions at repulsive coupling

Completing and experimentally validating the unified calcium-based model of NMDA receptor-dependent bidirectional synaptic plasticity: metaplastic stabilization, non-NMDA calcium sources, and the predicted long-delay pre-post LTD window

Realistic stereo statistics and multi-component PCA in unsupervised models of ocular dominance and disparity tuning (questions left open by Shouval, Intrator, Law & Cooper, 1996)

Robustness and generality of orientation and ocular-dominance map formation in the BCM lateral-inhibition network trained on natural stereo images (Shouval–Intrator–Cooper, 1997)

Origin and experimental test of the lateral-connectivity scaffold for developing orientation preference maps in primary visual cortex

Multiple calcium entry pathways in the calcium-dependent plasticity model with calcium homeostasis: consequences for synaptic stability, input selectivity, and pathway dominance

Realistic-noise robustness, waveform generality, and SNR-estimate sensitivity of SNR-dependent unmatched-filter time-of-arrival estimation in high noise

Presynaptic release probability versus postsynaptic efficacy as the carrier of simple-cell receptive-field structure in visual cortex: an untested experimental discrimination and its consequences for spatiotemporal dynamics and coding under short-term synaptic depression

Completing the Bienenstock-Cooper-Munro theory of synaptic modification: first-principles form of the modification function, cortical circuitry, modulatory control, and general stability

Quantifying and causally testing deprived-eye lateral geniculate nucleus firing-rate correlations in monocular-inactivation ocular-dominance plasticity

Open problems in the non-equilibrium chemical master equation theory of phosphorylation–dephosphorylation cycles: energy cost of bistability, n-step generalization, cycle variants, transient dynamics, and flux-controlled plasticity

Establishing whether stochastic short-term synaptic and dendritic dynamics uniquely account for multi-spike synaptic plasticity in visual cortex and hippocampus

Open questions from Perrone and Cooper's Generalized Ensemble Method: finite-sample weight estimation, principled member selection, and ensemble saturation

Biophysical implementation of the BCM moving modification threshold and its functional dependence on postsynaptic activity

General analytical theory of the AOWA adaptive time-of-flight estimation scheme: multi-outlier-class extension, robustness to classifier mis-specification, and worst-case energy

Correlated-noise-induced long lifetimes of BCM synapses: robustness of the spectral mechanism beyond the linearized, uniform-correlation, thermodynamic-limit analysis, and its mapping to monocular-deprivation experiments

Quantitative validation of the calcium-dependent GluR1 phosphorylation model of bidirectional synaptic plasticity in intact dendritic spines

Regimes of validity and physiological grounding of the calcium-control-hypothesis (CaDP) framework of synaptic plasticity: parameters, rate-rule averaging, and the predicted pre-before-post LTD window

Open quantitative core of the Cooper–Stölan strongly coupled shell model: exact cycle-weight function f(α) with its analytic continuation f(−1), and the magnitude of the omitted non-BCS graphs

Breakdown of flux quantization by generalized pairing in superconducting cylinders: the Schwartz–Cooper intermediate-flux regime

Robustness of direction-selectivity formation in natural-scene environments to multi-delay architectures and cortical recurrence